1561-1564
| 17 -(3-Furyl)-5-androstane-3,14,17 -triol (PST 2238). A Very Potent Antihypertensive Agent with a Novel Mechanism of Action
Luisa Quadri,
Giuseppe Bianchi,
Alberto Cerri,
Giorgio Fedrizzi,
Patrizia Ferrari,
Mauro Gobbini,
Piero Melloni,
Simona Sputore, and
Marco Torri
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1565-1569
| Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid D-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy
Thomas J. Tucker,
William C. Lumma,
S. Dale Lewis,
Stephen J. Gardell,
Bobby J. Lucas,
Elizabeth P. Baskin,
Richard Woltmann,
Joseph J. Lynch,
Elizabeth A. Lyle,
Sandra D. Appleby,
I-Wu Chen,
Kimberley B. Dancheck, and
Joseph P. Vacca
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1570-1577
| Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase
Jeffrey A. Robl,
Chong-Qing Sun,
Jay Stevenson,
Denis E. Ryono,
Ligaya M. Simpkins,
Maria P. Cimarusti,
Tamara Dejneka,
William A. Slusarchyk,
Sam Chao,
Leslie Stratton,
Raj N. Misra,
Mark S. Bednarz,
Magdi M. Asaad,
Hong Son Cheung,
Benoni E. Abboa-Offei,
Patricia L. Smith,
Parker D. Mathers,
Maxine Fox,
Thomas R. Schaeffer,
Andrea A. Seymour, and
Nick C. Trippodo
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1578-1584
| Aroyl(aminoacyl)pyrroles, a New Class of Anticonvulsant Agents
John R. Carson,
Richard J. Carmosin,
Philip M. Pitis,
Jeffry L. Vaught,
Harold R. Almond,
James P. Stables,
Harold H. Wolf,
Ewart A. Swinyard, and
H. Steve White
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1585-1599
| Substituted Hexahydrobenzo[f]thieno[c]quinolines as Dopamine D1-Selective Agonists: Synthesis and Biological Evaluation in Vitro and in Vivo
Michael R. Michaelides,
Yufeng Hong,
Stanley DiDomenico, Jr.,
Erol K. Bayburt,
Karen E. Asin,
Donald R. Britton,
Chun Wel Lin, and
Kazumi Shiosaki
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1600-1607
| Synthesis and Pharmacological Properties of a Close Analogue of an Antithrombotic Pentasaccharide (SR 90107A/ORG 31540)
Maurice Petitou,
Philippe Duchaussoy,
Guy Jaurand,
Françoise Gourvenec,
Isidore Lederman,
Jean-Marc Strassel,
Tereza Bârzu,
Bertrand Crépon,
Jean-Pascal Hérault,
Jean-Claude Lormeau,
André Bernat, and
Jean-Marc Herbert
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1608-1618
| Anticancer and Antiviral Effects and Inactivation of S-Adenosyl-L-homocysteine Hydrolase with 5'-Carboxaldehydes and Oximes Synthesized from Adenosine and Sugar-Modified Analogues
Stanislaw F. Wnuk,
Chong-Sheng Yuan,
Ronald T. Borchardt,
Jan Balzarini,
Erik De Clercq, and
Morris J. Robins
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1619-1633
| 1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2
Ish K. Khanna,
Richard M. Weier,
Yi Yu,
Paul W. Collins,
Julie M. Miyashiro,
Carol M. Koboldt,
Amy W. Veenhuizen,
Jerry L. Currie,
Karen Seibert, and
Peter C. Isakson
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1634-1647
| 1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents
Ish K. Khanna,
Richard M. Weier,
Yi Yu,
Xiang D. Xu,
Francis J. Koszyk,
Paul W. Collins,
Carol M. Koboldt,
Amy W. Veenhuizen,
William E. Perkins,
Jacquelen J. Casler,
Jaime L. Masferrer,
Yan Y. Zhang,
Susan A. Gregory,
Karen Seibert, and
Peter C. Isakson
[Full Article -
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1648-1656
| Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 2. Three-Dimensional Quantitative Structure-Activity Relationships of Hydantoin-Phenylpiperazine Derivatives with Affinity for 5-HT1A and 1 Receptors. A Comparison of CoMFA Models
María L. López-Rodríguez,
Ma Luisa Rosado,
Bellinda Benhamú,
Ma José Morcillo,
Esther Fernández, and
Klaus-Jürgen Schaper
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1657-1667
| Halogenated 4-(Phenoxymethyl)piperidines as Potential Radiolabeled Probes for  -1 Receptors: In Vivo Evaluation of [123I]-1-(Iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]piperidine
Rikki N. Waterhouse,
Karine Mardon,
Katrina M. Giles,
T. Lee Collier, and
Joanne C. O'Brien
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1668-1681
| Anesthetic Activity of Novel Water-Soluble 2-Morpholinyl Steroids and Their Modulatory Effects at GABAA Receptors
Alison Anderson,
Andrew C. Boyd,
Alan Byford,
Alexander C. Campbell,
David K. Gemmell,
Niall M. Hamilton,
David R. Hill,
Claire Hill-Venning,
Jeremy J. Lambert,
Maurice S. Maidment,
Valerie May,
Richard J. Marshall,
John A. Peters,
David C. Rees,
Donald Stevenson, and
Hardy Sundaram
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1682-1689
| Structure-Activity Relationships of N 2-Aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as Selective Endothelin Receptor-A Antagonists
Chengde Wu,
Ming F. Chan,
Fiona Stavros,
B. Raju,
Ilya Okun, and
Rosario S. Castillo
[Full Article -
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1690-1697
| Discovery of TBC11251, a Potent, Long Acting, Orally Active Endothelin Receptor-A Selective Antagonist
Chengde Wu,
Ming F. Chan,
Fiona Stavros,
B. Raju,
Ilya Okun,
Seymour Mong,
Karin M. Keller,
Tommy Brock,
Timothy P. Kogan, and
Richard A. F. Dixon
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1698-1706
| Chemometric Methodologies in a Quantitative Structure-Activity Relationship Study: The Antibacterial Activity of 6-Aminoquinolones
Violetta Cecchetti,
Enrica Filipponi,
Arnaldo Fravolini,
Oriana Tabarrini,
Daniela Bonelli,
Monica Clementi,
Gabriele Cruciani, and
Sergio Clementi
[Full Article - PDF] |
1707-1719
| Design, Synthesis, and Evaluation of Tetrahydropyrimidinones as an Example of a General Approach to Nonpeptide HIV Protease Inhibitors
George V. De Lucca,
Jing Liang,
Paul E. Aldrich,
Joe Calabrese,1a
Beverly Cordova,
Ronald M. Klabe,
Marlene M. Rayner, and
Chong-Hwan Chang1b
[Full Article -
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1720-1725
| 7-Spiroindanyl Derivatives of Naltrexone and Oxymorphone as Selective Ligands for  Opioid Receptors
S. Ohkawa,
B. DiGiacomo,
D. L. Larson,
A. E. Takemori, and
P. S. Portoghese
[Full Article - PDF] |
1726-1730
| Modulation of Melphalan Resistance in Glioma Cells with a Peripheral Benzodiazepine Receptor Ligand-Melphalan Conjugate
Lidia Kupczyk-Subotkowska,
Teruna J. Siahaan,
Anthony S. Basile,
Henry S. Friedman,
Patricia E. Higgins,
Di Song, and
James M. Gallo
[Full Article - PDF] |
1731-1737
| Synthesis, Structure, and Antiproliferative Activity of Selenophenfurin, an Inosine 5'-Monophosphate Dehydrogenase Inhibitor Analogue of Selenazofurin
Palmarisa Franchetti,
Loredana Cappellacci,
Ghassan Abu Sheikha,
Hiremagalur N. Jayaram,
Vivek V. Gurudutt,
Thaw Sint,
Bryan P. Schneider,
William D. Jones,
Barry M. Goldstein,
Graziella Perra,
Antonella De Montis,
Anna Giulia Loi,
Paolo La Colla, and
Mario Grifantini
[Full Article - PDF] |
1738-1748
| Biological and Conformational Examination of Stereochemical Modifications Using the Template Melanotropin Peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp- Ala-Lys]-NH2, on Human Melanocortin Receptors
Carrie Haskell-Luevano,
Gregory Nikiforovich,
Shubh D. Sharma,
Ying-Kui Yang,
Chris Dickinson,
Victor J. Hruby, and
Ira Gantz
[Full Article - PDF] |
1749-1754
| Synthesis and Oral Efficacy of a 4-(Butylethylamino)pyrrolo[2,3-d]pyrimidine: A Centrally Active Corticotropin-Releasing Factor1 Receptor Antagonist
Yuhpyng L. Chen,
Robert S. Mansbach,
Steven M. Winter,
Elizabeth Brooks,
Judith Collins,
Michael L. Corman,
Audrey R. Dunaiskis,
W. Stephen Faraci,
Randall J. Gallaschun,
Anne Schmidt, and
David W. Schulz
[Full Article - PDF] |
1755-1761
| Arylcarbamate Derivatives of 1-Piperidineethanol as Potent Ligands for 5-HT4 Receptors
Jean-Louis Soulier,
Donglai Yang,
Béatrice Brémont,
Tiziano Croci,
Umberto Guzzi, and
Michel Langlois
[Full Article - PDF] |
1762-1762
| The Dopamine Receptors Edited by K. A. Neve and R. L. Neve. Humana Press, Totowa, NJ. 1997. xi + 533 pp. 16 × 23 cm. ISBN-0-89603. $119.50.
Richard E. Mewshaw
[Full Article - PDF] |
1762-1762
| Books of Interest
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